|Posted by George on January 14, 2017 at 10:25 AM|
WESTERN CAROLINAS ACS SEMINAR
FREE TO THE PUBLIC!!
"Dynamic Nuclear Polarization-Enhanced NMR Studies of Nanoparticles."
Dr. Leah Casabianca
TUESDAY JANUARY 24, 2017
University of South Carolina Upstate
Olin B. Sansbury, Jr. Campus Life Center
800 University Way
Spartanburg, SC 29303
Order of Events:
6:00 pm – Meet and Greet Olin B. Sansbury, Jr. Campus Life Center
6:30 pm Dinner (Optional) Olin B. Sansbury, Jr. Campus Life Center (Room 309)
$18 Members/$5 High School Teachers and Student Members
Ø House Salad
Ø Cranberry chicken
Ø Glazed carrots
Ø Basil Orzo
Ø Chocolate cake
Ø Coffee, tea, water
7:30 pm Lecture Olin B. Sansbury, Jr. Campus Life Center
**We ask that you RSVP if you are attending the seminar and/or having dinner.
Please RSVP by TUESDAY JANUARY 17, 2017 to: [email protected] and leave your name, contact number or email address, how many will be attending seminar and/or dinner and if student or high school teacher status is applicable.
Dynamic Nuclear Polarization-Enhanced NMR Studies of Nanoparticles
Abstract: Nuclear Magnetic Resonance (NMR) is one of the most versatile techniques for atomic-level structural characterization of chemical systems ranging from small organic molecules to large systems such as proteins or materials. One of the main disadvantages of NMR, however, is its low sensitivity. One way to enhance the sensitivity of NMR that has gained recent popularity is called Dynamic Nuclear Polarization (DNP). DNP relies on the transfer of polarization from unpaired electrons to nearby nuclei. Normally, the unpaired electrons are introduced into the sample by doping the sample of interest with organic free radicals, although naturally occurring paramagnetic defects can be used as polarization agents as well. In this talk, we will present the results of two studies. In the first, we show that intrinsic paramagnetic defects in the diamond lattice can be used as DNP polarization agents to increase the 13C NMR signal of carbons in nanodiamonds. In the second, we discuss the development of HighlY-effective Polymer/Radical beads (HYPR-beads) which are organic nanoparticles that have been doped with a known hydrophobic DNP polarizing agent. HYPR-beads have been used to polarize 13C and 7Li nuclei in aqueous environments at low overall radical concentrations, and without the need for an added glassing co-solvent.
Bio: Dr. Casabianca received a B. S. degree in chemistry from Rice University in 2002 where she did undergraduate research with Prof. Seiichi P.T. Matsuda. She completed her Ph. D. in the lab of Prof. Angel C. de Dios at Georgetown University in 2008. Her thesis work involved using solution-state NMR and chemical shift calculations to understand the mechanism of action of anti-malarial drugs. She then did a postdoctoral fellowship (2008-2010) with Prof. Yoshitaka Ishii at the University of Illinois at Chicago working on structural characterization of graphite oxide. Her second postdoctoral fellowship was in the group of Prof. Lucio Frydman at the Weizmann Institute (2010-2013) where she worked on dynamic nuclear polarization of diamond samples. She joined the faculty at Clemson University in 2014.